Section: New Results

multi-electrode array measurement

In the context of the CardioXComp project, in collaboration with the REO team and the company Notocord, we proposed a strategy to analyze the signals acquired by multi-electrode array (MEA) on cultures of hiPSC-CMs cells with drug compounds, and to automatically deduce the channels affected by the drug. First, in [10], we study how MEA meausrement can be modeled in such a way that the produced in-silico signals are comparable to real ones. The main problems concern the heterogenities of cell cultures. Then, in [20] a method based on parameter identification, by comparing the in-silico and real signals, was used on signals acquired with commercial systems on cell culture with various drugs. The IC-50 and dose-response of several drugs could be assessed. This kind of techniques could contribute to promote the technology based on MEA and hiPSC-CMs.